Transplantation-surgeons and organ-receiver all over the world
seek already
since years a
method, which makes the repulsion-reaction at transplanted
organs impossible. This method was by me already 1990 [3]
discussed, but unfortunately without positive reaction of
competent surgeons. Now however appeared by examples from
Israel, Italy and the USA, that my theory is right. In this
report at first are theoretical considerations and then concrete
examples of immune-tolerance-induction discussed.
We know
already on the one hand of the medicine-study and on the other
hand form the practical medical experience, that binovular
twins with different blood-groups, which were connected with
each other through their placentas, all their life tolerate the
blood-groups of the other twin. Likewise we know, that bacterial
infections in the bone-marrow by own powers are not able to be
refused, and also we know, that micro-metastases of malignomas
in the bone marrow the defence of the malignoma prevent.
Now, what have
this three proved facts common? It is not among other things the
poor blood-perfusion in the bone marrow, which prevents the
defence in the bone marrow, how once a colleague maintained [4],
but the common fact is the contact of strange-anti-genes with
the unripened immune-system of the bone-marrow! This contact
releases now in the bone marrow the formation of
immune-tolerance-factors, which migrate from there out into the
periphery and program the hole immune-system so, that no
defence-reactions against that aforesaid antigens occure. This
can now be strange antigens of the HLA-system or bacteria or
allergens. At antigens of the HLA-system and allergens is here
the immune-tolerance desired, at bacteria however undesired.
How can we now
concrete at organ-transplantations the repulsion-reaction
prevent?
While we win
from the organ-donor additional HLA-competent cells and implant
them into the bone-marrow-space of the organ-receiver. This can
f.i. be cells of the abdomen-net or
bone-marrow stem-cells, which are problem-less able to be taken
out.
Merely at the
bone-marrow-transplantation it occurs otherwise: if the
leukaemia-sick man after annihilation of his own bone-marrow
from the received secondary bone-marrow has a graft-versus-host
reaction (GVHR) or such a reaction is to be feared, so one takes
a bloating of HLA-competent cells from the receiver and injects
them into the bone-marrow-space of the receiver, where there is
the unripened immune-system of the secondary bone-marrow.
Thereby is also here induced the desired immuntolerance.
And now to
the concrete examples of organ-transplantations, at which this
principle has become realized: Dr. Susanne Ildstad [ 2] at the
University of Pittsburgh, leaded after experiments at the mouse
in a pilot-study at five patients an organ-transplantation,
whereby as a concomitant action also bone-marrow from the
organ-donor was additional transplanted, when before the
T-helper-cells were out of it removed, but the so-called
promote-cells were leaved behind. It came neither to an
organ-repulsion nor to a GVHR, although at four patients only
three surface-antigens of the HLA-system instead of the
otherwise usual six corresponded and at one organ-receiver
generally no HLA-corresponding existed.
What had
happened? HLA-competent cells of the donor came into contact
with the unripened immune-system in the bone-marrow-space of the
receiver. But also reverse originated a contact of HLA-competent
cells of the receiver with the unripened immune-system of the
donor, because the stem-cells of the donor, likewise how these
of the receiver divide themselves and build during their
ripening HLA-surface-antigens. It came thus to a cross-immuntolerance-induction.
Therefore the colleague would have could spare the removing of
the T-helper-cells and would have the same success, i.e., she
needed at none of the organ-receivers immun-supressivas.
Proof: Prof.
Yair Reisner [1] from the Weitzman-institute in Israel leaded at
numerous leukaemia-sick persons a bone-marrow-transplantation
without annihilation of the receiver-bone marrow before. Also
here the HLA-surface-antigens corresponded unconventional
rarely, and it came also after months to no GVHR. Also here no
immunsupressiva were required. But thereby the
leukaemia-stem-cells were not annihilated, a disadvantage for
the further sickness-progress.
Right would
have been, to destroy the leukaemia-cells, then to lead a
bone-marrow-donation and simultaneous to implant HLA-competent
cells out of the body of the receiver into his
bone-marrow-space, in order, that an intensive contact with the
unripened immune-system of the secondary bone-marrow occurs.
Worthy
readers, I hope, among you exist competent avantguardists, who
wish to transpose the logic of this report into fact.
Authority:
1.) BILD DER
WISSENSCHAFT Nr.4/ 1995, S.10, 11, "Die Menge macht´s"
2.) BILD DER
WISSENSCHAFT Nr.6/ 1995, S.106, 108 "Milde Spende"
3.) Dr.
Silberbauer, Zur Immuntoleranzinduktion bei
Organtransplantationen", ÄRZTE WOCHE, 4.Jahrgang Nr. 4, S.6
4.) Doz.
Dr. Christoph Zielinski, "Tumore sind wenig antigen" ÄRZTE WOCHE
, 4. Jahrgang,
Nr.4, S.6
5.) Medical
Tribune Nr.40, .Okt. 1991, S.16 ""Artfremde Transplantate
überleben ganz ohne Immunsupression!“
6.) Arzt und
Praxis, 49. Jahrgang, 731, S.560, "Lebertransplantation bei
Erwachsenen"
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